Molecular pharmacology of opioid receptor mechanisms.
نویسندگان
چکیده
منابع مشابه
Molecular mechanisms of opioid receptor signal transduction.
The analgesic and antidiarrhoeal uses of opium were known to the Sumerians and predynastic Egyptians. During 5000 years of medicinal use, opium has become associated with countries, cultures and prominent individuals, and through several modifications, remains an extensively used analgesic and addictive drug. Morphine, the principle active compound in opium, was first isolated by the German che...
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Opioids are among the most effective analgesics available and are the first choice in the treatment of acute severe pain. However, partial efficacy, a tendency to produce tolerance, and a host of ill-tolerated side effects make clinically available opioids less effective in the management of chronic pain syndromes. Given that most therapeutic opioids produce their actions via µ-opioid receptors...
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Opioid receptors have been targeted for the treatment of pain and related disorders for thousands of years and remain the most widely used analgesics in the clinic. Mu (μ), kappa (κ), and delta (δ) opioid receptors represent the originally classified receptor subtypes, with opioid receptor like-1 (ORL1) being the least characterized. All four receptors are G-protein coupled and activate inhibit...
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The cloning of the opioid-receptor-like 1 (ORL(1)) receptor and the identification of nociceptin as its endogenous agonist have revealed a new G-protein-coupled receptor signalling system. The structural and functional homology of ORL(1) to the opioid receptor systems has posed a number of challenges in understanding the often competing physiological responses elicited by these G-protein-couple...
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In this study, we investigated the effect of nicotinic receptor agonists and antagonists on the analgesic response to morphine in the formalin test. In experiments conducted in mice, nicotine produced an early dose-dependent analgesic effect. At a dose of 0.5 mg/kg, mecamylamine, a nicotinic receptor inhibitor, suppressed the analgesic effect induced by 0.1 mg/kg nicotine in both stages of th...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 1989
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.94.339